Estrogens Attenuate Oxidative Stress and the Differentiation and Apoptosis of Osteoblasts by DNA-Binding-Independent Actions of the ERα

@inproceedings{Almeida2010EstrogensAO,
  title={Estrogens Attenuate Oxidative Stress and the Differentiation and Apoptosis of Osteoblasts by DNA-Binding-Independent Actions of the ERα},
  author={Maria de F{\'a}tima Menezes Santos Almeida and Marta Martin-Millan and Elena Ambrogini and Robert W. Bradsher and Li Han and Xiao-Dong Chen and Paula K Roberson and Robert S. Weinstein and C A O'brien and Robert L. Jilka and Stavros C Manolagas},
  booktitle={Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  year={2010}
}
Estrogens diminish oxidative stress in bone and bone marrow, attenuate the generation of osteoblasts, and decrease the prevalence of mature osteoblast apoptosis. We have searched for the molecular mechanism of these effects using as tools a mouse model bearing an estrogen receptor alpha (ERalpha) knock-in mutation that prevents binding to DNA (ERalpha(NERKI/-)) and several osteoblast progenitor cell models expressing the wild-type ERalpha or the ERalpha(NERKI/-). We report that the ability of… CONTINUE READING
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