Estrogens, phytoestrogens and colorectal neoproliferative lesions

  title={Estrogens, phytoestrogens and colorectal neoproliferative lesions},
  author={Michele Barone and Sabina Tanzi and Katia Lofano and Maria Principia Scavo and Raffaella Guido and Lucia Demarinis and Maria Beatrice Principi and Antongiulio Bucci and Alfredo Di Leo},
  journal={Genes & Nutrition},
Epidemiological and experimental studies suggest a protective role of estrogens against colorectal cancer. This effect seems to be mediated by their binding to estrogen receptor beta (ER-β), one of the two estrogen receptors with high affinity for these hormones. Very recently, the demonstration of an involvement of ER-β in the development of adenomatous polyps of the colon has also been documented, suggesting the use of selective ER-β agonists in primary colorectal cancer prevention… CONTINUE READING