Estrogens, enzyme variants, and breast cancer: a risk model.

  title={Estrogens, enzyme variants, and breast cancer: a risk model.},
  author={Philip S Crooke and Marylyn DeRiggi Ritchie and David L. Hachey and Sheila Dawling and Nady Roodi and Fritz F. Parl},
  journal={Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology},
  volume={15 9},
Oxidative metabolites of estrogens have been implicated in the development of breast cancer, yet relatively little is known about the metabolism of estrogens in the normal breast. We developed a mathematical model of mammary estrogen metabolism based on the conversion of 17beta-estradiol (E(2)) by the enzymes cytochrome P450 (CYP) 1A1 and CYP1B1, catechol-O… CONTINUE READING