Estrogenic status modulates aryl hydrocarbon receptor--mediated hepatic gene expression and carcinogenicity.

Abstract

Estrogenic status is thought to influence the cancer risk in women and has been reported to affect toxicity of carcinogenic polycyclic aromatic hydrocarbons (PAHs) in animals. The objective of this study was to examine the influence of estradiol (E2) on hepatic gene expression changes mediated by 7,12-dimethylbenz(a)anthracene (DMBA), a potent PAH. Sprague… (More)
DOI: 10.1093/carcin/bgm288

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