Estrogenic endpoints in fish early life-stage tests: luciferase and vitellogenin induction in estrogen-responsive transgenic zebrafish.

@article{Bogers2006EstrogenicEI,
  title={Estrogenic endpoints in fish early life-stage tests: luciferase and vitellogenin induction in estrogen-responsive transgenic zebrafish.},
  author={Rinus Bogers and Esther Mutsaerds and Jeanette Druke and Daphne F de Roode and Albertinka Jacoba Murk and Bart van der Burg and Juliette Legler},
  journal={Environmental toxicology and chemistry},
  year={2006},
  volume={25 1},
  pages={241-7}
}
This study incorporated specific endpoints for estrogenic activity in the early life-stage (ELS) test, as described in Guideline 210 of the Organization for Economic Cooperation and Development and traditionally used for toxicity screening of chemicals. A transgenic zebrafish model expressing an estrogen receptor-mediated luciferase reporter gene was exposed to ethinylestradiol (EE2), and luciferase activity as well as vitellogenin (VTG) was measured. Concentrations of EE2 were tested at 1, 3… CONTINUE READING
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