Estrogenic endocrine disruptive components interfere with calcium handling and differentiation of human trophoblast cells.

@article{Derfoul2003EstrogenicED,
  title={Estrogenic endocrine disruptive components interfere with calcium handling and differentiation of human trophoblast cells.},
  author={Assia Derfoul and Florence Lin and Emmanuel M. Awumey and T Kolodzeski and D J David J Hall and Rocky S Tuan},
  journal={Journal of cellular biochemistry},
  year={2003},
  volume={89 4},
  pages={755-70}
}
During development, calcium (Ca) is actively transported by placental trophoblasts to meet fetal nutritional and the skeletal mineralization needs. Maternal exposure to estrogenic pesticides, such as 1,1-bis(p-chlorophenyl)-2,2,2-trichloroethane (DDT) and methoxychlor (MTC), has been shown to result in reproductive disorders and/or abnormal fetal development. In this study, we have examined the effects of exposure of trophoblastic cells to MTC and DTT, in comparison to 17beta-estradiol (E2) and… CONTINUE READING

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