Estrogenic effects of two derivatives of icariin on human breast cancer MCF-7 cells.

@article{Ye2005EstrogenicEO,
  title={Estrogenic effects of two derivatives of icariin on human breast cancer MCF-7 cells.},
  author={H. Ye and Y. Lou},
  journal={Phytomedicine : international journal of phytotherapy and phytopharmacology},
  year={2005},
  volume={12 10},
  pages={
          735-41
        }
}
  • H. Ye, Y. Lou
  • Published 2005
  • Chemistry, Medicine
  • Phytomedicine : international journal of phytotherapy and phytopharmacology
The aims of the present study were to determine the estrogenic activities of icariin (ICA) and its derivatives and their structure-estrogenic activity relationship. Therefore, icaritin (ICT) and desmethylicaritin (DICT) were derived from ICA. The estrogenic activities of ICA, ICT and DICT were examined by cell proliferation and progestogen receptor mRNA expression of estrogen-receptor-positive MCF-7 cells. Current studies exhibited that ICT and DICT both markedly enhanced the proliferation of… Expand
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