Estrogenic effects of genistein on the growth of estrogen receptor-positive human breast cancer (MCF-7) cells in vitro and in vivo.

@article{Hsieh1998EstrogenicEO,
  title={Estrogenic effects of genistein on the growth of estrogen receptor-positive human breast cancer (MCF-7) cells in vitro and in vivo.},
  author={Chinq Yi Hsieh and Ross C. Santell and Sandra Z. Haslam and William G Helferich},
  journal={Cancer research},
  year={1998},
  volume={58 17},
  pages={
          3833-8
        }
}
Genistein, found in soy products, is a phytochemical with several biological activities. In the current study, our research focused on the estrogenic and proliferation-inducing activity of genistein. We have demonstrated that genistein enhanced the proliferation of estrogen-dependent human breast cancer (MCF-7) cells in vitro at concentrations as low as 10 nM, with a concentration of 100 nM achieving proliferative effects similar to those of 1 nM estradiol. Expression of the estrogen-responsive… CONTINUE READING

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