Estrogenic effects of environmental chemicals: an interspecies comparison.

  title={Estrogenic effects of environmental chemicals: an interspecies comparison.},
  author={C. M. Olsen and Elise T M Meussen-Elholm and Jan Kenneth Hongslo and J\orgen Herman Vogt Stenersen and K Tollefsen},
  journal={Comparative biochemistry and physiology. Toxicology & pharmacology : CBP},
  volume={141 3},
The development of various in vitro screening methods has led to identification of novel estrogenic chemicals of natural and anthropogenic origin. In this study, the (anti)estrogenic potential of several environmental chemicals were compared in an array of in vitro test systems comprising: (i) competitive binding to estrogen receptors derived from the human breast cancer cell line MCF-7 (hER) and rainbow trout (Oncorhynchus mykiss) (rtER), (ii) a proliferation assay with MCF-7 cells (E-SCREEN… CONTINUE READING
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