Estrogenic effects of a methanol extract of the fruit of Brenania brieyi de Wild (Rubiaceae)

@article{Nde2006EstrogenicEO,
  title={Estrogenic effects of a methanol extract of the fruit of Brenania brieyi de Wild (Rubiaceae)},
  author={C. M. Magne Nde and D. Njamen and Jean Claude Mbanya and O. Zierau and G. Vollmer and Zacharias Tanee Fomum},
  journal={Journal of Natural Medicines},
  year={2006},
  volume={61},
  pages={86-89}
}
  • C. M. Magne Nde, D. Njamen, +3 authors Zacharias Tanee Fomum
  • Published 2006
  • Chemistry
  • Journal of Natural Medicines
  • Fruit of the Cameroonian medicinal tree Brenania brieyi is used in the treatment of endocrine disorders, including menopausal complaints. To assess the potential estrogenicity, 50 mg/kg BW/day of a methanol extract from Brenania brieyi fruit was administered intravaginally twice a day to ovariectomized female Wistar rats for 3 and 7 days. The uterine weight doubled within 7 days, and the vaginal epithelial height increased both after 3 and 7 days of treatment. In conclusion, the results suggest… CONTINUE READING
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