Estrogenic activity of octylphenol, nonylphenol, bisphenol A and methoxychlor in rats.

  title={Estrogenic activity of octylphenol, nonylphenol, bisphenol A and methoxychlor in rats.},
  author={Susan C Laws and Stephan A. Carey and Janet M Ferrell and G J Bodman and Ralph L. Cooper},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  volume={54 1},
Considerable attention has recently been focused on environmental chemicals that disrupt the reproductive system by altering steroid receptor function. Although numerous in vitro and in vivo methods have been shown to be useful approaches for identifying chemicals that can disrupt reproduction through a direct interaction with the estrogen receptor, it is imperative that the protocols selected be capable of detecting chemicals with a broad range of estrogenic activity. Here we evaluate the… CONTINUE READING
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