Estrogenic activity of musk fragrances detected by the E-screen assay using human mcf-7 cells.

@article{Bitsch2002EstrogenicAO,
  title={Estrogenic activity of musk fragrances detected by the E-screen assay using human mcf-7 cells.},
  author={Nikola Bitsch and Csilla Dudas and Wilfried K{\"o}rner and Klaus Failing and Scarlett Biselli and Gabriella Rimkus and Hubertus Brunn},
  journal={Archives of environmental contamination and toxicology},
  year={2002},
  volume={43 3},
  pages={257-64}
}
The widespread use of synthetic musk fragrances and the resultant presence of these substances and their metabolites in the aquatic environment (as well as their accumulation in human adipose tissue) raises the question of whether musk fragrances display endocrine and in particular estrogenic activity. A variety of musk fragrances were tested using the E-screen assay. A statistically significant increase in proliferation rate of human MCF-7 breast cancer cells was detected for two nitro musks… CONTINUE READING

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