Estrogenic activity of glabridin and glabrene from licorice roots on human osteoblasts and prepubertal rat skeletal tissues

@article{Somjen2004EstrogenicAO,
  title={Estrogenic activity of glabridin and glabrene from licorice roots on human osteoblasts and prepubertal rat skeletal tissues},
  author={D. Somjen and S. Katzburg and J. Vaya and A. Kaye and S. Tamir},
  journal={The Journal of Steroid Biochemistry and Molecular Biology},
  year={2004},
  volume={91},
  pages={241-246}
}
Data from both in vivo and in vitro experiments demonstrated that glabridin and glabrene are similar to estradiol-17beta in their stimulation of the specific activity of creatine kinase, although at higher concentrations, but differ in their extent of action and interaction with other drugs. In pre-menopausal human bone cells, the response to estradiol-17beta and glabridin (at higher concentration) was higher than in post-menopausal cells; whereas, glabrene (at higher concentration) was more… Expand
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