Estrogenic activity of glabridin and glabrene from licorice roots on human osteoblasts and prepubertal rat skeletal tissues

@article{Somjen2004EstrogenicAO,
  title={Estrogenic activity of glabridin and glabrene from licorice roots on human osteoblasts and prepubertal rat skeletal tissues},
  author={D. Somjen and S. Katzburg and J. Vaya and A. Kaye and S. Tamir},
  journal={The Journal of Steroid Biochemistry and Molecular Biology},
  year={2004},
  volume={91},
  pages={241-246}
}
  • D. Somjen, S. Katzburg, +2 authors S. Tamir
  • Published 2004
  • Chemistry, Medicine
  • The Journal of Steroid Biochemistry and Molecular Biology
    • Data from both in vivo and in vitro experiments demonstrated that glabridin and glabrene are similar to estradiol-17beta in their stimulation of the specific activity of creatine kinase, although at higher concentrations, but differ in their extent of action and interaction with other drugs. In pre-menopausal human bone cells, the response to estradiol-17beta and glabridin (at higher concentration) was higher than in post-menopausal cells; whereas, glabrene (at higher concentration) was more… CONTINUE READING
    View on Elsevier
    library.tasmc.org.il
    50 Citations
    Highly Influential Citations
    1
    Background Citations
    17
    Methods Citations
    2
    50 Citations
    Citation Type

    Citation Type

    Estrogenicity of Glabridin in Ishikawa Cells
    • 11
    • PDF
    Phytoestrogenic Compounds and Their Synthetic Analogs, Contrary to Estradiol- 17b Stimulates Human Derived Female Cultured Bone Cells in Hyperglycemic Conditions
    • 5
    Ethyl Acetate Extract of Licorice Root (Glycyrrhiza glabra) Enhances Proliferation and Osteogenic Differentiation of Human Bone Marrow Mesenchymal Stem Cells
    • 4
    Agonistic and antagonistic estrogens in licorice root (Glycyrrhiza glabra)
    • 38
    • PDF
    Responsiveness to phytoestrogens in primary human osteoblasts is modulated differentially by a “less-calcemic” analog of 1,25 dihydroxyvitamin D3: JK 1624F2-2 (JKF)
    • 8
    Absorption of dietary licorice isoflavan glabridin to blood circulation in rats.
    • 31
    • PDF
    Estrogenic activities of extracts of Chinese licorice (Glycyrrhiza uralensis) root in MCF-7 breast cancer cells
    • 37
    • PDF
    Glabridin and glycyrrhizic acid show no beneficial effect on the chemical composition and mechanical properties of bones in ovariectomized rats, when administered in moderate dose.
    • 6
    Phytochemistry and biological properties of glabridin.
    • 102
    Molecular Docking Studies of Glycyrrhizic Acid (GA), Glycyrrhetic Acid (GE) and Glabridin (GLA) with Estrogen Receptors (ERs)
    • 1

    References

    SHOWING 1-10 OF 35 REFERENCES
    Estrogen-like activity of licorice root constituents: glabridin and glabrene, in vascular tissues in vitro and in vivo
    • 74
    • PDF
    Estrogen-like activity of glabrene and other constituents isolated from licorice root
    • 203
    Estrogenic and antiproliferative properties of glabridin from licorice in human breast cancer cells.
    • 173
    • PDF
    Effects of phytoestrogens on DNA synthesis and creatine kinase activity in vascular cells.
    • 34
    • PDF
    The Synthetic Phytoestrogen, Ipriflavone, and Estrogen Prevent Bone Loss by Different Mechanisms
    • 53
    The antioxidative effects of the isoflavan glabridin on endogenous constituents of LDL during its oxidation.
    • 140
    Vitamin D analogs modulate the action of gonadal steroids in human vascular cells in vitro.
    • 33
    • PDF
    Nonhypercalcemic Analogs of Vitamin D Stimulate Creatine Kinase B Activity in Osteoblast-Like ROS 17/2.8 Cells and Up-regulate Their Responsiveness to Estrogens
    • 21
    • PDF
    Reciprocal modulation by sex steroid and calciotrophic hormones of skeletal cell proliferation
    • 26
    Phytoestrogen genistein stimulates the production of osteoprotegerin by human trabecular osteoblasts
    • 116