Estrogenic activity of glabridin and glabrene from licorice roots on human osteoblasts and prepubertal rat skeletal tissues

@article{Somjen2004EstrogenicAO,
  title={Estrogenic activity of glabridin and glabrene from licorice roots on human osteoblasts and prepubertal rat skeletal tissues},
  author={Dalia Somjen and Sara Katzburg and Jacob Vaya and Alvin M. Kaye and David Hendel and Gary H. Posner and Snait Tamir},
  journal={The Journal of Steroid Biochemistry and Molecular Biology},
  year={2004},
  volume={91},
  pages={241-246}
}
  • D. Somjen, S. Katzburg, S. Tamir
  • Published 1 August 2004
  • Biology, Medicine
  • The Journal of Steroid Biochemistry and Molecular Biology

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Estrogenic and antiproliferative properties of glabridin from licorice in human breast cancer cells.
TLDR
This is the first study to indicate that isoflavans have estrogen-like activities, and glabridin and its derivatives exhibited varying degrees of estrogen receptor agonism in different tests and demonstrated growth-inhibitory actions on breast cancer cells.
The Synthetic Phytoestrogen, Ipriflavone, and Estrogen Prevent Bone Loss by Different Mechanisms
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Findings indicate that IP is effective in preventing the ovx-associated bone loss and the bone protective mechanisms of IP in ovarian hormone deficiency may be different from those of E2 and may involve increased rates of bone formation.
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