Estrogenic activity of glabridin and glabrene from licorice roots on human osteoblasts and prepubertal rat skeletal tissues
@article{Somjen2004EstrogenicAO, title={Estrogenic activity of glabridin and glabrene from licorice roots on human osteoblasts and prepubertal rat skeletal tissues}, author={Dalia Somjen and Sara Katzburg and Jacob Vaya and Alvin M. Kaye and David Hendel and Gary H. Posner and Snait Tamir}, journal={The Journal of Steroid Biochemistry and Molecular Biology}, year={2004}, volume={91}, pages={241-246} }
56 Citations
Estrogenicity of Glabridin in Ishikawa Cells
- BiologyPloS one
- 2015
The results suggest that the combination of glabridin and 17β-E2 might be better suited for providing high estrogenic effects with lower incidences of endometrial cancer that is associated with 17α-estradiol.
Phytoestrogenic Compounds and Their Synthetic Analogs, Contrary to Estradiol- 17b Stimulates Human Derived Female Cultured Bone Cells in Hyperglycemic Conditions
- Biology
- 2011
Cultured female- derived human osteoblasts (hObs) responded by different parameters to the phytoestrogens: daidzein (D), glabrene (Gla) and glabridin (Glb), to their synthetic derivatives;…
Ethyl Acetate Extract of Licorice Root (Glycyrrhiza glabra) Enhances Proliferation and Osteogenic Differentiation of Human Bone Marrow Mesenchymal Stem Cells
- BiologyIranian journal of pharmaceutical research : IJPR
- 2018
The results showed a significant increase in proliferation in presence of LE, indicating that the stimulatory effects of LE occur through estrogen receptor-mediated mechanism, and LE may be a potential candidate for prevention of osteoporosis in menopausal women.
Agonistic and antagonistic estrogens in licorice root (Glycyrrhiza glabra)
- BiologyAnalytical and bioanalytical chemistry
- 2011
Most fractions displaying superinduction were rich in flavonoids with single prenylation, including glabridin, which was able to reduce the estrogenic response of E2 by approximately 80% at 6 × 10−6 M, whereas glabrene-rich fractions only exhibited agonistic responses, preferentially on ERα.
Responsiveness to phytoestrogens in primary human osteoblasts is modulated differentially by a “less-calcemic” analog of 1,25 dihydroxyvitamin D3: JK 1624F2-2 (JKF)
- BiologyThe Journal of Steroid Biochemistry and Molecular Biology
- 2006
Absorption of dietary licorice isoflavan glabridin to blood circulation in rats.
- Chemistry, BiologyJournal of nutritional science and vitaminology
- 2007
Dietary glabridin was at least partly incorporated into the body in an unchanged form, though most dietary flavonoids are converted to non-active conjugate forms during intestinal absorption.
Estrogenic activities of extracts of Chinese licorice (Glycyrrhiza uralensis) root in MCF-7 breast cancer cells
- BiologyThe Journal of Steroid Biochemistry and Molecular Biology
- 2009
Glabridin and glycyrrhizic acid show no beneficial effect on the chemical composition and mechanical properties of bones in ovariectomized rats, when administered in moderate dose.
- Biology, MedicinePharmacological reports : PR
- 2016
Molecular Docking Studies of Glycyrrhizic Acid (GA), Glycyrrhetic Acid (GE) and Glabridin (GLA) with Estrogen Receptors (ERs)
- Chemistry, Biology
- 2017
GLA, not GA and GE, is a partial ERs agonist and could be further modified to design novel semi-synthetic post-menopausal drugs.
References
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This is the first study to indicate that isoflavans have estrogen-like activities, and glabridin and its derivatives exhibited varying degrees of estrogen receptor agonism in different tests and demonstrated growth-inhibitory actions on breast cancer cells.
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Findings indicate that IP is effective in preventing the ovx-associated bone loss and the bone protective mechanisms of IP in ovarian hormone deficiency may be different from those of E2 and may involve increased rates of bone formation.
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Phytoestrogen genistein stimulates the production of osteoprotegerin by human trabecular osteoblasts
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