Estrogenic activity of glabridin and glabrene from licorice roots on human osteoblasts and prepubertal rat skeletal tissues

@article{Somjen2004EstrogenicAO,
  title={Estrogenic activity of glabridin and glabrene from licorice roots on human osteoblasts and prepubertal rat skeletal tissues},
  author={Dalia Somjen and Sara Katzburg and Jacob Vaya and Alvin M. Kaye and David Hendel and Gary H. Posner and Snait Tamir},
  journal={The Journal of Steroid Biochemistry and Molecular Biology},
  year={2004},
  volume={91},
  pages={241-246}
}
  • D. Somjen, S. Katzburg, S. Tamir
  • Published 1 August 2004
  • Biology, Medicine
  • The Journal of Steroid Biochemistry and Molecular Biology
View on Elsevier
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Estrogenicity of Glabridin in Ishikawa Cells
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The results suggest that the combination of glabridin and 17β-E2 might be better suited for providing high estrogenic effects with lower incidences of endometrial cancer that is associated with 17α-estradiol.
Phytoestrogenic Compounds and Their Synthetic Analogs, Contrary to Estradiol- 17b Stimulates Human Derived Female Cultured Bone Cells in Hyperglycemic Conditions
Cultured female- derived human osteoblasts (hObs) responded by different parameters to the phytoestrogens: daidzein (D), glabrene (Gla) and glabridin (Glb), to their synthetic derivatives;…
Ethyl Acetate Extract of Licorice Root (Glycyrrhiza glabra) Enhances Proliferation and Osteogenic Differentiation of Human Bone Marrow Mesenchymal Stem Cells
TLDR
The results showed a significant increase in proliferation in presence of LE, indicating that the stimulatory effects of LE occur through estrogen receptor-mediated mechanism, and LE may be a potential candidate for prevention of osteoporosis in menopausal women.
Agonistic and antagonistic estrogens in licorice root (Glycyrrhiza glabra)
TLDR
Most fractions displaying superinduction were rich in flavonoids with single prenylation, including glabridin, which was able to reduce the estrogenic response of E2 by approximately 80% at 6 × 10−6 M, whereas glabrene-rich fractions only exhibited agonistic responses, preferentially on ERα.
Responsiveness to phytoestrogens in primary human osteoblasts is modulated differentially by a “less-calcemic” analog of 1,25 dihydroxyvitamin D3: JK 1624F2-2 (JKF)
Absorption of dietary licorice isoflavan glabridin to blood circulation in rats.
TLDR
Dietary glabridin was at least partly incorporated into the body in an unchanged form, though most dietary flavonoids are converted to non-active conjugate forms during intestinal absorption.
Estrogenic activities of extracts of Chinese licorice (Glycyrrhiza uralensis) root in MCF-7 breast cancer cells
Glabridin and glycyrrhizic acid show no beneficial effect on the chemical composition and mechanical properties of bones in ovariectomized rats, when administered in moderate dose.
Phytochemistry and biological properties of glabridin.
Molecular Docking Studies of Glycyrrhizic Acid (GA), Glycyrrhetic Acid (GE) and Glabridin (GLA) with Estrogen Receptors (ERs)
TLDR
GLA, not GA and GE, is a partial ERs agonist and could be further modified to design novel semi-synthetic post-menopausal drugs.
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References

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Estrogen-like activity of licorice root constituents: glabridin and glabrene, in vascular tissues in vitro and in vivo
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Estrogenic and antiproliferative properties of glabridin from licorice in human breast cancer cells.
TLDR
This is the first study to indicate that isoflavans have estrogen-like activities, and glabridin and its derivatives exhibited varying degrees of estrogen receptor agonism in different tests and demonstrated growth-inhibitory actions on breast cancer cells.
Effects of phytoestrogens on DNA synthesis and creatine kinase activity in vascular cells.
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Findings indicate that IP is effective in preventing the ovx-associated bone loss and the bone protective mechanisms of IP in ovarian hormone deficiency may be different from those of E2 and may involve increased rates of bone formation.
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TLDR
The data suggest that the phytoestrogen genistein is capable of upregulating the production of OPG by human osteoblasts, and dietary sources of phy toestrogens may help to prevent bone resorption and bone loss by enhanced osteoblastic production ofOPG.
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