Estrogenic GPR30 signalling induces proliferation and migration of breast cancer cells through CTGF.

@article{Pandey2009EstrogenicGS,
  title={Estrogenic GPR30 signalling induces proliferation and migration of breast cancer cells through CTGF.},
  author={Deo P. Pandey and Rosamaria Lappano and Lidia Albanito and Antonio Madeo and Marcello Maggiolini and Didier Picard},
  journal={The EMBO journal},
  year={2009},
  volume={28 5},
  pages={523-32}
}
The steroid hormone oestrogen can signal through several receptors and pathways. Although the transcriptional responses mediated by the nuclear oestrogen receptors (ER) have been extensively characterized, the changes in gene expression elicited by signalling through the membrane-associated ER GPR30 have not been studied. We show here for ER-negative human breast cancer cells that the activation of GPR30 signalling by oestrogen or by hydroxytamoxifen (OHT), an ER antagonist but GPR30 agonist… CONTINUE READING

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