Estrogenic Activities of Nitrophenols in Diesel Exhaust Particles1

@inproceedings{Furuta2004EstrogenicAO,
  title={Estrogenic Activities of Nitrophenols in Diesel Exhaust Particles1},
  author={Chie Furuta and Akira K. Suzuki and Shinji Taneda and Kazuyuki Kamata and Hideyuki Hayashi and Yoki Mori and Chunmei Li and Gen Watanabe and Kazuyoshi Taya},
  booktitle={Biology of reproduction},
  year={2004}
}
Abstract We recently isolated 3-methyl-4-nitrophenol (4-nitro-m-cresol; PNMC) and 4-nitro-3-phenylphenol (PNMPP) from diesel exhaust particles (DEP) and identified them as vasodilators. Because these compounds are alkylphenolic derivatives that might mimic hormones, we evaluated their estrogenic activity by using recombinant yeast screens, myometrial contractility assays, and in vivo uterotrophic assays. Recombinant yeast screen assays showed that both PNMC and PNMPP possess estrogenic activity… Expand
Estrogenic and anti-androgenic activities of 4-nitrophenol in diesel exhaust particles.
TLDR
The results suggest that diesel exhaust emissions and the degradation of parathion can lead to accumulation of PNP in air, water, and soil and thus could have serious deleterious effects on wildlife and human health. Expand
Immunohistological study for estrogenic activities of nitrophenols in diesel exhaust particles
TLDR
Results clearly show the estrogenic activity of PNMC and PNMPP by cell proliferation on the uterine luminal epithelium as well as vasodilators and xenoestrogens. Expand
4-Nitrophenol isolated from diesel exhaust particles disrupts regulation of reproductive hormones in immature male rats
TLDR
Findings clearly show that PNP influences the hypothalamic–pituitary–gonadal axis in immature male rats, with decreased secretion of LH and FSH and increased secretion of testosterone and inhibin. Expand
Anti-androgenic activity of 3-methyl-4-nitrophenol in diesel exhaust particles.
TLDR
The results demonstrate that PNMC in diesel exhaust particles clearly has anti-androgenic activity both in vitro and in vivo and can therefore be considered as an endocrine-disrupting chemical. Expand
Endocrine Disruptive Effect of 3-Methyl-4-nitrophenol Isolated from Diesel Exhaust Particles in Hershberger Assay Using Castrated Immature Rats
TLDR
Plasma follicle-stimulating hormone (FSH) and luteinizing hormone (LH) levels significantly decreased under all the doses in the PN MC treatment groups, indicating that PNMC acts on the hypothalamus-pituitary axis. Expand
Effects of 3-methyl-4-nitrophenol in diesel exhaust particles on the regulation of testicular function in immature male rats.
TLDR
It is suggested that PNMC has a direct effect on the testes of immature male rats, causing a reduction in testosterone secretion. Expand
Effects of 3-methyl-4-nitrophenol on the suppression of adrenocortical function in immature male rats.
TLDR
Results clearly show that PNMC has a direct effect on the adrenal gland to reduce corticosterone secretion, and the associated increase in plasma ACTH is probably due decreased negative feedback regulation by cortic testosterone. Expand
Nitrophenols isolated from diesel exhaust particles promote the growth of MCF-7 breast adenocarcinoma cells.
TLDR
Results clearly indicate that PNMC and PNMPP do not show genotoxicity but act as tumor promoters in an estrogen receptor alpha-predominant breast cancer cell line. Expand
Nitrophenols isolated from diesel exhaust particles regulate steroidogenic gene expression and steroid synthesis in the human H295R adrenocortical cell line.
TLDR
S steroidogenic enzymes are clarified as candidates responsible for the inhibition or stimulation for the production of steroid hormones in the steroidogenic pathway, thus providing the first experimental evidence for multiple mechanisms of disruption of endocrine pathways by these nitrophenols. Expand
Effects of 3-methyl-4-nitrophenol in diesel exhaust particles on the regulation of reproductive function in immature female Japanese quail (Coturnix japonica).
TLDR
It is indicated that PNMC induces reproductive toxicity at the central level and disrupts reproductive function in the immature female quail. Expand
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References

SHOWING 1-10 OF 50 REFERENCES
Environmentally persistent alkylphenolic compounds are estrogenic.
TLDR
It is shown that a number of alkylphenolic compounds, used in a variety of commercial products and found in river water, are estrogenic in fish, birds, and mammals and capable of stimulating vitellogenin gene expression in trout hepatocytes, gene transcription in transfected cells, and the growth of breast cancer cell lines. Expand
Investigation of Vasodilatory Substances in Diesel Exhaust Particles (DEP): Isolation and Identification of Nitrophenol Derivatives
Vasodilatory compounds in the weak acidic fraction of a benzene extract of diesel exhaust particles (DEP) were fractionated by column chromatography through silica gel, and the chemical structures ofExpand
Lung carcinogenesis and formation of 8-hydroxy-deoxyguanosine in mice by diesel exhaust particles.
TLDR
The results suggest that the induction of oxidative DNA damage may be an important factor in the initiation of DEP-induced lung carcinogenesis, and that beta-carotene and high dietary fat may play a role in the regulation of tumour development via modulation of the formation of 8-OHdG. Expand
hemotaxis and Biodegradation of 3-Methyl-- Nitrophenol by Ralstonia sp . SJ 98
i p m ( i 3-Methyl-4-nitrophenol is one of the major breakown products of fenitrothion [O,O-dimethyl O-(3ethyl-4-nitrophenyl) thiophosphate], a recalcitrant rganophosphate insecticide used inExpand
Anti-estrogenic activity of diesel exhaust particles.
TLDR
It is thought that those compounds in DEP can modulate the activity of estrogen, leading to the distruption of balance between estrogen and androgen. Expand
Isolation of nitrophenols from diesel exhaust particles (DEP) as vasodilatation compounds.
TLDR
The compounds in diesel exhaust particles (DEP) that are responsible for vasodilatation were isolated and characterized for the first time and caused dilatation of rat thoracic artery and the other two nitrophenols also showed vasodILatation activities. Expand
DIESEL EXHAUST (DE) AFFECTS THE REGULATION OF TESTICULAR FUNCTION IN MALE FISCHER 344 RATS
TLDR
Diesel exhaust particles at 0.3 mg/m3 significantly decreased prostate and coagulating gland weights, accompanied by a reduction in thymus and adrenal gland weight, and there was a significant rise in the weights of prostate, seminal vesicles, andCoagulating glands in the 3 mg/ m3 DE group. Expand
Exposure to diesel exhaust affects the male reproductive system of mice.
TLDR
It is proposed here that diesel exhaust is an environmental pollutant with the potential to influence male reproductive function and a no-observed-adverse-effect level (NOAEL) was observed with approximately 30 micrograms DEP/m3, which is lower than the WHO-recommended limit. Expand
Biological effects of diesel exhaust particles. I. In vitro production of superoxide and in vivo toxicity in mouse.
TLDR
It was suggested that most parts of DEP toxicity in lungs are due to active oxygen radicals such as O2.- and .OH, and that the cause of death is due to pulmonary edema mediated by endothelial cell damage. Expand
Estrogenic and anti-estrogenic activities of two types of diesel exhaust particles.
TLDR
Both type-1 and type-2 DEP possess estrogenic and anti-estrogenic activities, and extracts of both types decreased the activity of estrogen. Expand
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