Estrogen withdrawal from osteoblasts and osteocytes causes increased mineralization and apoptosis.


Recent studies have demonstrated increased bone mineral heterogeneity following estrogen withdrawal in vivo. Such changes likely contribute to fracture risk during post-menopausal osteoporosis since tissue mineralization is correlated with bone strength and stiffness. However, the cellular mechanisms responsible for increased mineral variability have not… (More)
DOI: 10.1055/s-0033-1363265


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