Estrogen up-regulates inducible nitric oxide synthase, nitric oxide, and cyclooxygenase-2 in splenocytes activated with T cell stimulants: role of interferon-gamma.

@article{Karpuzoglu2006EstrogenUI,
  title={Estrogen up-regulates inducible nitric oxide synthase, nitric oxide, and cyclooxygenase-2 in splenocytes activated with T cell stimulants: role of interferon-gamma.},
  author={Ebru Karpuzoglu and Jillian Beth Fenaux and Rebecca A. Phillips and Andrea J. Lengi and François Elvinger and S. Ansar Ahmed},
  journal={Endocrinology},
  year={2006},
  volume={147 2},
  pages={
          662-71
        }
}
Estrogen is implicated in many autoimmune diseases and is a robust immunomodulator. For example, it regulates interferon (IFN)-gamma, a cytokine believed to up-regulate inducible nitric oxide synthase (iNOS). A notable gap in the literature is a lack of information on the regulation of nitric oxide in immune tissues by estrogen. We now show that activation of splenocytes with T cell stimulants [concanavalin-A (Con-A) or anti-CD3 antibodies] results in copious release of nitric oxide in… CONTINUE READING

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