Estrogen treatment for acromegaly

@article{Shimon2012EstrogenTF,
  title={Estrogen treatment for acromegaly},
  author={Ilan Shimon and Ariel L. Barkan},
  journal={Pituitary},
  year={2012},
  volume={15},
  pages={601-607}
}
Estrogens have been used in patients with acromegaly since the 1930–1940s, suppressing plasma IGF-1 levels and improving clinical signs and symptoms of acromegaly. Estrogens antagonize GH function at the post-receptor level, inhibiting GH signaling, thus decreasing GH-induced hepatic IGF-1 synthesis. We report our experience with four female patients with active acromegaly, naïve to medical treatment or inadequately controlled by somatostatin receptor ligands (SRLs) or the GH-receptor… 

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