Estrogen treatment alleviates NMDA-antagonist induced hippocampal LTP blockade and cognitive deficits in ovariectomized mice.

@article{Gureviciene2003EstrogenTA,
  title={Estrogen treatment alleviates NMDA-antagonist induced hippocampal LTP blockade and cognitive deficits in ovariectomized mice.},
  author={Irina Gureviciene and Jukka T. Puoliv{\"a}li and Raimo Pussinen and Jun Wang and Heikki Tanila and Aarne Ylinen},
  journal={Neurobiology of learning and memory},
  year={2003},
  volume={79 1},
  pages={72-80}
}
Estrogen is implicated in hippocampus-dependent spatial learning as well as structural organization and electrophysiological properties of the rat hippocampus but little is known about its mechanisms of action in mice. In this study, we investigated pharmacologically whether estrogen interacts with the hippocampal N-methyl-D-aspartate (NMDA) receptors in ovariectomized mice as postulated for rats. Female C57BL/6J mice were ovariectomized at 5 months, and 2 weeks before testing at 12 months… CONTINUE READING