Estrogen therapy and liver function—metabolic effects of oral and parenteral administration

  title={Estrogen therapy and liver function—metabolic effects of oral and parenteral administration},
  author={B. V. VON Schoultz and K. Carlstroem and L. Collste and A. Eriksson and P. Henriksson and A. Pousette and R. Stege},
  journal={The Prostate},
  • B. V. VON Schoultz, K. Carlstroem, +4 authors R. Stege
  • Published 1989
  • Medicine, Biology
  • The Prostate
  • Oral estrogen therapy for prostatic cancer is clinically effective but also accompanied by severe cardiovascular side effects. Hypertension, venous thromboembolism, and other cardiovascular disorders are associated with alterations in liver metabolism. The impact of exogenous estrogens on the liver is dependent on the route of administration and the type and dose of estrogen. Oral administration of synthetic estrogens has profound effects on liver‐derived plasma proteins, coagulation factors… CONTINUE READING
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