Estrogen sulfation genes, hormone replacement therapy, and endometrial cancer risk.

  title={Estrogen sulfation genes, hormone replacement therapy, and endometrial cancer risk.},
  author={Timothy R. Rebbeck and Andrea B. Troxel and Yiting Wang and Amy H. Walker and Saarene Panossian and Stephen Gallagher and Ekaterina G Shatalova and Rebecca Blanchard and Greta R. Bunin and Angela DeMichele and Stephen C. Rubin and Mona Baumgarten and Michelle Berlin and Rita Schinnar and Jesse A Berlin and Brian L. Strom},
  journal={Journal of the National Cancer Institute},
  volume={98 18},
BACKGROUND Unopposed estrogen replacement therapy is associated with increased risk of endometrial cancer. To investigate the mechanism of this association, we evaluated whether risk of endometrial cancer was associated with the genotypes involved in steroid hormone metabolism and the duration of exogenous hormone use. METHODS A population-based case-control study in nine counties of the Philadelphia metropolitan area was undertaken with 502 case patients with endometrial cancer and 1326 age… CONTINUE READING


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