Estrogen sulfatase and estrogen sulfotransferase in human primary mammary carcinoma.

@article{Tseng1983EstrogenSA,
  title={Estrogen sulfatase and estrogen sulfotransferase in human primary mammary carcinoma.},
  author={L. Tseng and J. Mazella and L. Y. Lee and M. L. Stone},
  journal={Journal of steroid biochemistry},
  year={1983},
  volume={19 4},
  pages={
          1413-7
        }
}
Estrogen sulfatase (ES) and estrogen sulfotransferase (ESFT) activities were measured in a group of primary breast tumors. The mean value of ES activities, measured in 66 breast tumor specimens, was 0.9 nmol of estrone formed from estrone sulfate/mg tissue protein per hr regardless of the hormone receptor status of the specimen. However, the average value of the ESFT activity, expressed in nmol of estradiol-3-sulfate (E2S) formed from estradiol (E2)/mg of cytosol protein per hr, was found to be… Expand
Estrogen sulfotransferase and steroid sulfatase in human breast carcinoma.
TLDR
Results from the present study suggest that immunoreactivities for both EST and STS are associated with their mRNA level and enzymatic activity and that EST immunoreactivity is considered to be a potent prognostic factor in human breast carcinoma. Expand
Expression of hydroxysteroid sulphotransferase is related to estrogen receptor status in human mammary cancer.
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The coordinated expression of hydroxysteroid sulphotransferase, estrogen sulphot Transformerase, and ER, supports the concept of a functional relationship between estrogen action via ER and sulphurylation reactions. Expand
Expression of Estrogen Sulfotransferase 1E1 and Steroid Sulfatase in Breast Cancer: A Immunohistochemical Study
TLDR
The hypothesis that STS is overexpressed in breast cancer and associated with a worse prognosis is supported and the significance of the association between EST1E1 and ER-β or PR-B should be further studied since these two receptors are transcription activators and may regulate the expression of protective enzymes like EST1 E1. Expand
Estrone sulfatase versus estrone sulfotransferase in human breast cancer: potential clinical applications
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It is concluded that the inhibition of sulfatase and the stimulation of sulfotransferase activity can open interesting possibilities to explore these effects in patients with breast cancer. Expand
Steroid sulfatase and estrogen sulfotransferase in human carcinomas
TLDR
STS/EST status was associated with intratumoral estrogen level in the colon carcinoma, and STS-negative/EST-positive colon carcinomas patients had longer survival, and further investigations are required. Expand
Estrogen-metabolizing enzymes in breast cancers from women over the age of 80 years.
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The importance of aromatase is relatively increased in EldCa, and this may elucidate the role of EMEs in the absence of ovarian estrogens in the pathogenesis of breast cancer. Expand
Expression of cytosolic sulfotransferases in normal mammary epithelial cells and breast cancer cell lines.
TLDR
Understanding the regulation of ST activity in normal breast cells and normal breast cell lines will improve knowledge of the role of sulfation in breast cancer and provide a model with which to study the mechanism of action of estrogens in mammary cells. Expand
Control of estrone sulfatase activity in human breast cancer cells: effect of tibolone and its metabolites
TLDR
Using intact cells and physiological concentrations of estrone sulfate, the conversion to estradiol was very intense in the hormone-dependent (T-47D, MCF-7) breast cancer cells, but very little or noEstradiol wa... Expand
Estradiol-17beta sulfotransferase activity in canine osteosarcoma D17 cells.
TLDR
The results suggest that EST may have a role in the local metabolism of estrogens in bone and HPLC profiles showed a limited metabolism of Estradiol to other compounds except for estrone, which was clearly present in both free and sulfate fractions. Expand
Importance of estrogen sulfates in breast cancer.
TLDR
It is concluded that in breast cancer, the control of the sulfatase and 17 beta-hydroxysteroid dehydrogenase activities, which are key steps in the formation of estradiol in the breast, can open new possibilities in the treatment of hormone-dependent mammary cancer. Expand
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Estrogen sulfotransferase activity and estrogen receptor levels were measured in 32 human primary breast cancer cytosol preparations and levels in receptor-negative tumors were significantly lower than the levels inceptor-positive tumors. Expand
A relationship between estrogen sulfurylation and estrogen and progesterone receptor status in human mammary carcinoma.
It was previously demonstrated that a correlation existed between estrogen receptor (ER) status and levels of estrogen sulfotransferase in human mammary cancer, high levels being associated withExpand
Estrogen sulfurylation as an alternative indicator of hormone dependence in human breast cancer
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An alternative simple method, having a high potential for the evaluation of hormone responsiveness in mammary cancer, is suggested, which chooses a discriminating value for estrogen sulfurylation of 40 pmole per mg protein per 2 hr. Expand
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It is concluded that estrogen sulfates can act in vitro as estrogen precursors in mammary tumor cells and were found to be active on MCF7 cells in inducing secreted proteins of 46,000 and 160,000 mol wt which are induced by a 10-fold lower concentration of unconjugated estrone and estradiol. Expand
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TLDR
Data indicate that progesterone secretion during the luteal phase is responsible for the induction of both E2 dehydrogenase and sulfotransferase activities in the endometrium, suggesting that these enzymes are closely coupled, resulting in the rapid metabolism of E2 by formation and excretion of estrone sulfate. Expand
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It is suggested that dehydroepiandrosterone sulfate formation in the tumors is mainly controlled by the sulfotransferase, which acts as a shunt in regulating the level of free dehydration, and related compounds, available for metabolism to steroids influencing the growth of mammary epithelial cells. Expand
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Investigations have indicated that the cyclic variation in endometrial estrogen sulfurylation may control the availability of 17 beta-estradiol to the cytoplasmic receptor, and a specific inhibitor, 3-methoxy-4-nitroestrone, will help in establishing the role of uterine and mammary estrogen sulfurelation. Expand
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