Estrogen stimulates brain-derived neurotrophic factor expression in embryonic mouse midbrain neurons through a membrane-mediated and calcium-dependent mechanism.

@article{Ivanova2001EstrogenSB,
  title={Estrogen stimulates brain-derived neurotrophic factor expression in embryonic mouse midbrain neurons through a membrane-mediated and calcium-dependent mechanism.},
  author={Tatiana Ivanova and E. W. Udo K{\"u}ppers and Juergen Engele and Cordian Beyer},
  journal={Journal of neuroscience research},
  year={2001},
  volume={66 2},
  pages={221-30}
}
We have provided evidence that 17beta-estradiol (E) synthesized in the midbrain promotes the differentiation of midbrain dopamine neurons through nonclassical steroid action. Because these developmental effects resemble those reported for brain-derived neurotrophic factor (BDNF), we hypothesized that E influences dopaminergic cell differentiation through a BDNF-dependent mechanism. Competitive RT-PCR and ELISA techniques were employed to study first the developmental pattern of BDNF and trkB… CONTINUE READING

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