Estrogen signaling multiple pathways to impact gene transcription.

@article{Marino2006EstrogenSM,
  title={Estrogen signaling multiple pathways to impact gene transcription.},
  author={Maria Marino and Paola Galluzzo and Paolo Ascenzi},
  journal={Current genomics},
  year={2006},
  volume={7 8},
  pages={
          497-508
        }
}
Steroid hormones exert profound effects on cell growth, development, differentiation, and homeostasis. Their effects are mediated through specific intracellular steroid receptors that act via multiple mechanisms. Among others, the action mechanism starting upon 17beta-estradiol (E2) binds to its receptors (ER) is considered a paradigmatic example of how steroid hormones function. Ligand-activated ER dimerizes and translocates in the nucleus where it recognizes specific hormone response elements… Expand
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