Estrogen signaling in livers of male mice with hepatocellular carcinoma induced by exposure to arsenic in utero.

@article{Waalkes2004EstrogenSI,
  title={Estrogen signaling in livers of male mice with hepatocellular carcinoma induced by exposure to arsenic in utero.},
  author={Michael P. Waalkes and Jie Liu and Hua Chen and Yaxiong Xie and William E Achanzar and Yun-Su Zhou and Min-Liang Cheng and Bhalchandra A. Diwan},
  journal={Journal of the National Cancer Institute},
  year={2004},
  volume={96 6},
  pages={466-74}
}
BACKGROUND Exposure of pregnant mice to inorganic arsenic induces a spectrum of tumors, including hepatocellular carcinoma (HCC), in their adult offspring similar to that induced by exposing adult mice to estrogenic compounds. To investigate whether arsenic exposure in utero causes altered estrogen signaling, we examined expression of estrogen receptor-alpha (ER-alpha), cyclin D1 (an estrogen-responsive hepatic oncogene), and several cytochrome P450 genes (with sexually dimorphic liver… CONTINUE READING

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Keefer for critically reviewing the manuscript

  • Leslie, Larry
  • Manuscript received July 16,
  • 2003

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