Estrogen-responsive genes newly found to be modified by TCDD exposure in human cell lines and mouse systems

@article{Tanaka2007EstrogenresponsiveGN,
  title={Estrogen-responsive genes newly found to be modified by TCDD exposure in human cell lines and mouse systems},
  author={Junko Tanaka and Junzo Yonemoto and Hiroko Zaha and Ryoiti Kiyama and Hideko Sone},
  journal={Molecular and Cellular Endocrinology},
  year={2007},
  volume={272},
  pages={38-49}
}
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) can induce estrogenic action or inhibit estrogen-induced effects in various tissues because of aryl hydrocarbon receptor (AhR)-estrogen receptor (ER) cross-talk. In order to identify the biomarkers of TCDD endocrine disruption, we screened estrogen-responsive genes modified by TCDD exposure using specific cDNA microarrays spotted with estrogen-responsive genes. MCF-7 human breast carcinoma cells and RL95-2 human endometrial carcinoma cells were exposed… CONTINUE READING

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