Estrogen represses SOX9 during sex determination in the red-eared slider turtle Trachemys scripta.

@article{Barske2010EstrogenRS,
  title={Estrogen represses SOX9 during sex determination in the red-eared slider turtle Trachemys scripta.},
  author={Lindsey Barske and Blanche Capel},
  journal={Developmental biology},
  year={2010},
  volume={341 1},
  pages={305-14}
}
Production of male offspring in viviparous eutherian mammals requires a sex-determining mechanism resistant to maternal hormones. This constraint is relaxed in egg-laying species, which are sensitive to hormones during sex determination and often use an increase in aromatase, the estrogen-synthesizing enzyme, as a key feminizing signal. In the turtle Trachemys scripta, sex is normally determined by temperature, but estrogen treatment overrides this cue and leads exclusively to female… CONTINUE READING