Estrogen replacement suppresses pressor response and oxidative stress induced by cage-switch stress in ovariectomized rats.

@article{Morimoto2008EstrogenRS,
  title={Estrogen replacement suppresses pressor response and oxidative stress induced by cage-switch stress in ovariectomized rats.},
  author={Keiko Morimoto and Masami Uji and T. Ueyama and Hiroyuki Kimura and Tomomi Kohno and Akira Takamata and Shigenobu Yano and Ken-ichi Yoshida},
  journal={Annals of the New York Academy of Sciences},
  year={2008},
  volume={1148},
  pages={
          213-8
        }
}
We examined the suppressive effects of estradiol on psychological stress-induced cardiovascular responses and oxidative stress in ovariectomized rats, both placebo-treated (OVX+Pla) and estrogen-treated (OVX+E2). The elevations in blood pressure and heart rate induced by cage-switch stress were attenuated in the OVX+E2 as compared with the OVX+Pla group. N(G)-nitro-L-arginine methyl ester, administered via drinking water, reduced the difference in these responses. Furthermore, this stress… CONTINUE READING
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