Estrogen replacement reduces PGHS-2-dependent vasoconstriction in the aged rat.

@article{Armstrong2002EstrogenRR,
  title={Estrogen replacement reduces PGHS-2-dependent vasoconstriction in the aged rat.},
  author={Stephen J. Armstrong and Yunlong Zhang and Ken G. Stewart and Sandra T Davidge},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2002},
  volume={283 3},
  pages={H893-8}
}
The reduction in estrogen in postmenopausal women contributes to an increase in vascular dysfunction. Models of aging have shown that this is due, in part, to increased prostaglandin H synthase (PGHS)-dependent vasoconstriction. We showed previously that inducible PGHS-2-dependent vasoconstriction is increased with aging. In the present study, we hypothesized that estrogen suppresses PGHS-2-dependent constriction in the aged rat. Isolated mesenteric arteries from placebo- or estrogen-treated… CONTINUE READING
7 Citations
38 References
Similar Papers

References

Publications referenced by this paper.
Showing 1-10 of 38 references

Similar Papers

Loading similar papers…