Estrogen relaxes coronary arteries by opening BKCa channels through a cGMP-dependent mechanism.

@article{White1995EstrogenRC,
  title={Estrogen relaxes coronary arteries by opening BKCa channels through a cGMP-dependent mechanism.},
  author={Richard E. White and David J. Darkow and J L Lang},
  journal={Circulation research},
  year={1995},
  volume={77 5},
  pages={936-42}
}
Women rarely suffer cardiovascular dysfunction before menopause, but by the age of 65 a woman becomes as vulnerable to cardiovascular mortality as a man. It has been proposed that estrogens protect against cardiovascular disease; however, the physiological basis of estrogen protection is unknown. In the present study the mechanism of estrogen-induced relaxation of coronary arteries was investigated at the tissue, cellular, and molecular levels. Tissue studies demonstrate that 17 beta-estradiol… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 125 extracted citations

Similar Papers

Loading similar papers…