Estrogen-related receptor alpha is a repressor of phosphoenolpyruvate carboxykinase gene transcription.

Abstract

The orphan nuclear receptor estrogen-related receptor (ERR) alpha is a downstream effector of the transcriptional coactivator PGC-1alpha in the regulation of genes important for mitochondrial oxidative capacity. PGC-1alpha is also a potent activator of the transcriptional program required for hepatic gluconeogenesis, and in particular of the key… (More)

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