Estrogen-related receptor alpha directs peroxisome proliferator-activated receptor alpha signaling in the transcriptional control of energy metabolism in cardiac and skeletal muscle.

@article{Huss2004EstrogenrelatedRA,
  title={Estrogen-related receptor alpha directs peroxisome proliferator-activated receptor alpha signaling in the transcriptional control of energy metabolism in cardiac and skeletal muscle.},
  author={Janice M. Huss and In{\'e}s Pineda Torra and Bart Staels and Vincent Gigu{\`e}re and D. P. Kelly},
  journal={Molecular and cellular biology},
  year={2004},
  volume={24 20},
  pages={9079-91}
}
Estrogen-related receptors (ERRs) are orphan nuclear receptors activated by the transcriptional coactivator peroxisome proliferator-activated receptor gamma (PPARgamma) coactivator 1alpha (PGC-1alpha), a critical regulator of cellular energy metabolism. However, metabolic target genes downstream of ERRalpha have not been well defined. To identify ERRalpha-regulated pathways in tissues with high energy demand such as the heart, gene expression profiling was performed with primary neonatal… CONTINUE READING
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