Estrogen-related abnormalities in glomerulosclerosis-prone mice: reduced mesangial cell estrogen receptor expression and prosclerotic response to estrogens.

@article{Potier2002EstrogenrelatedAI,
  title={Estrogen-related abnormalities in glomerulosclerosis-prone mice: reduced mesangial cell estrogen receptor expression and prosclerotic response to estrogens.},
  author={Myl{\`e}ne Potier and Michael Karl and Feng Zheng and Sharon J. Elliot and Gary E. Striker and Liliane J. Striker},
  journal={The American journal of pathology},
  year={2002},
  volume={160 5},
  pages={1877-85}
}
The development and progression of glomerulosclerosis (GS) is determined by the genetic background. The incidence of end-stage renal disease is increased in postmenopausal women, suggesting that estrogen deficiency may play a role in the accumulation of extracellular matrix by mesangial cells (MCs), which are primarily responsible for the synthesis and degradation of this matrix. Using mouse models that are prone or resistant to the development of GS, we compared the expression of estrogen… CONTINUE READING