Estrogen-related Receptor β Reduces the Subnuclear Mobility of Estrogen Receptor α and Suppresses Estrogen-dependent Cellular Function*

  title={Estrogen-related Receptor β Reduces the Subnuclear Mobility of Estrogen Receptor α and Suppresses Estrogen-dependent Cellular Function*},
  author={Takashi Tanida and K. Matsuda and S. Yamada and T. Hashimoto and M. Kawata},
  journal={The Journal of Biological Chemistry},
  pages={12332 - 12345}
  • Takashi Tanida, K. Matsuda, +2 authors M. Kawata
  • Published 2015
  • Biology, Medicine
  • The Journal of Biological Chemistry
  • Background: The role of orphan nuclear receptor ERRβ in estrogen-related pathophysiology is poorly understood. Results: ERRβ repressed the transactivity of ERα and proliferation of MCF-7 breast carcinoma cells through reduction of the intranuclear mobility of ERα. Conclusion: ERRβ affects ERα dynamics and function. Significance: Regulation of ERRβ will provide a potential therapeutic approach for estrogen-related cancer. Estrogen-related receptor (ERR) is a member of the nuclear receptor… CONTINUE READING
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