Estrogen-related Receptor β Reduces the Subnuclear Mobility of Estrogen Receptor α and Suppresses Estrogen-dependent Cellular Function.

@article{Tanida2015EstrogenrelatedR,
  title={Estrogen-related Receptor β Reduces the Subnuclear Mobility of Estrogen Receptor α and Suppresses Estrogen-dependent Cellular Function.},
  author={Takashi Tanida and Ken Matsuda and Shunji Yamada and Takeshi Hashimoto and Mitsuhiro Kawata},
  journal={The Journal of biological chemistry},
  year={2015},
  volume={290 19},
  pages={
          12332-45
        }
}
Estrogen-related receptor (ERR) is a member of the nuclear receptor superfamily that has strong homology with estrogen receptor (ER) α. ERR has three subtypes (α, β, and γ) expressed in estrogen-sensitive organs, including ovary, breast, and brain. No endogenous ligands of ERRs have been identified, but these receptors share a common DNA element with ERα and control estrogen-mediated gene transcription. Recent evidence suggests a role of ERRs in estrogen-related pathophysiology, but the… CONTINUE READING

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