Estrogen regulation of mammary gland development and breast cancer: amphiregulin takes center stage

@article{LaMarca2007EstrogenRO,
  title={Estrogen regulation of mammary gland development and breast cancer: amphiregulin takes center stage},
  author={Heather L LaMarca and Jeffrey M. Rosen},
  journal={Breast cancer research : BCR},
  year={2007},
  volume={9},
  pages={304 - 304}
}
Estrogen-mediated proliferation is fundamental to normal mammary gland development. Recent studies have demonstrated that amphiregulin is a critical paracrine regulator of estrogen action during ductal morphogenesis. These studies implicate a critical role for amphiregulin in mammary stem cell differentiation as well as breast cancer initiation and progression. 

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