Estrogen regulation of epidermal growth factor receptor messenger ribonucleic acid.

  title={Estrogen regulation of epidermal growth factor receptor messenger ribonucleic acid.},
  author={R B Lingham and George M. Stancel and David S Loose-Mitchell},
  journal={Molecular endocrinology},
  volume={2 3},
Previous studies have demonstrated that 17 beta-estradiol (E2) causes a 3-fold increase in epidermal growth factor (EGF) receptors in uterine membranes. We now report that the increase in uterine EGF receptor levels is due to an increase in the steady-state levels of EGF receptor mRNA. After a single E2 injection, EGF receptor mRNA levels, as determined by RNA blots, increase 3- to 4-fold between 1 and 3 h, remain elevated at 6 h, and decline between 12 and 18 h. The effect is specific for E2… CONTINUE READING
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