Estrogen regulation of cyclin E2 requires cyclin D1 but not c-Myc.

  title={Estrogen regulation of cyclin E2 requires cyclin D1 but not c-Myc.},
  author={Catherine Elizabeth Caldon and Claudio Marcelo Sergio and Judith Sch{\"u}tte and Marijke N Boersma and Robert Lyndsay Sutherland and Jason S. Carroll and Elizabeth A. Musgrove},
  journal={Molecular and cellular biology},
  volume={29 17},
During estrogen-induced proliferation, c-Myc and cyclin D1 initiate independent pathways that activate cyclin E1-Cdk2 by sequestration and/or downregulation of the CDK inhibitor p21(Waf1/Cip1), without significant increases in cyclin E1 protein levels. In contrast, cyclin E2 undergoes a marked increase in expression, which occurs within 9 to 12 h of estrogen treatment of antiestrogen-pretreated MCF-7 breast cancer cells. Both E cyclins are important to estrogen action, as small interfering RNA… CONTINUE READING