Estrogen regulates tumor growth through a nonclassical pathway that includes the transcription factors ERβ and KLF5.

Abstract

Clinical evidence suggests that antiestrogens inhibit the development of androgen-insensitive prostate cancer. Here, we show that the estrogen receptor β (ERβ) mediates inhibition by the antiestrogen ICI 182,780 (ICI) and its enhancement by estrogen. ERβ associated with gene promoters through the tumor-suppressing transcription factor KLF5 (Krüppel-like… (More)
DOI: 10.1126/scisignal.2001551

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