Estrogen regulates tumor growth through a nonclassical pathway that includes the transcription factors ERβ and KLF5.


Clinical evidence suggests that antiestrogens inhibit the development of androgen-insensitive prostate cancer. Here, we show that the estrogen receptor β (ERβ) mediates inhibition by the antiestrogen ICI 182,780 (ICI) and its enhancement by estrogen. ERβ associated with gene promoters through the tumor-suppressing transcription factor KLF5 (Krüppel-like… (More)
DOI: 10.1126/scisignal.2001551


Figures and Tables

Sorry, we couldn't extract any figures or tables for this paper.

Slides referencing similar topics