Estrogen regulates the development of brain-derived neurotrophic factor mRNA and protein in the rat hippocampus.

@article{Solum2002EstrogenRT,
  title={Estrogen regulates the development of brain-derived neurotrophic factor mRNA and protein in the rat hippocampus.},
  author={Derek T Solum and Robert J. Handa},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2002},
  volume={22 7},
  pages={2650-9}
}
During development, estrogen has a variety of effects on morphological and electrophysiological properties of hippocampal neurons. Brain-derived neurotrophic factor (BDNF) also plays an important role in the survival and differentiation of neurons during development. We examined the effects of gonadectomy with and without estrogen replacement on the mRNA and protein of BDNF and its receptor, trkB, during early postnatal development of the rat hippocampus. We used immunocytochemistry to… CONTINUE READING

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Sexual Differentiation of the Brain: Genes, Estrogen, and Neurotrophic Factors

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