Estrogen regulates the development of brain-derived neurotrophic factor mRNA and protein in the rat hippocampus.


During development, estrogen has a variety of effects on morphological and electrophysiological properties of hippocampal neurons. Brain-derived neurotrophic factor (BDNF) also plays an important role in the survival and differentiation of neurons during development. We examined the effects of gonadectomy with and without estrogen replacement on the mRNA… (More)


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