Estrogen regulates pulmonary alveolar formation, loss, and regeneration in mice.

@article{Massaro2004EstrogenRP,
  title={Estrogen regulates pulmonary alveolar formation, loss, and regeneration in mice.},
  author={Donald J. Massaro and Gloria Decarlo Massaro},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2004},
  volume={287 6},
  pages={
          L1154-9
        }
}
  • D. Massaro, G. Massaro
  • Published 1 December 2004
  • Biology, Medicine
  • American journal of physiology. Lung cellular and molecular physiology
Lung tissue elastic recoil and the dimension and number of pulmonary gas-exchange units (alveoli) are major determinants of gas-exchange function. Loss of gas-exchange function accelerates after menopause in the healthy aged and is progressively lost in individuals with chronic obstructive pulmonary disease (COPD). The latter, a disease of midlife and later, though more common in men than in women, is a disease to which women smokers and never smokers may be more susceptible than men; it is… 
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  • D. Massaro, G. Massaro
  • Biology, Medicine
    American journal of physiology. Lung cellular and molecular physiology
  • 2006
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TLDR
It is shown that ERβ is abundantly expressed and biologically active in the lung, and direct transcriptional regulation of these genes by ERβ was demonstrated, suggesting that estrogens act via ERβ in the lungs to modify PDGF-A and GM-CSF expression.
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TLDR
It is concluded that estrogen is responsible for the sexual dimorphism of the lung's gas-exchange region and induces the formation of smaller, more numerous alveoli in otherwise untreated female rats.
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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