Estrogen regulates pulmonary alveolar formation, loss, and regeneration in mice.

@article{Massaro2004EstrogenRP,
  title={Estrogen regulates pulmonary alveolar formation, loss, and regeneration in mice.},
  author={Donald J. Massaro and Gloria Decarlo Massaro},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2004},
  volume={287 6},
  pages={
          L1154-9
        }
}
  • D. Massaro, G. Massaro
  • Published 1 December 2004
  • Biology, Medicine
  • American journal of physiology. Lung cellular and molecular physiology
Lung tissue elastic recoil and the dimension and number of pulmonary gas-exchange units (alveoli) are major determinants of gas-exchange function. Loss of gas-exchange function accelerates after menopause in the healthy aged and is progressively lost in individuals with chronic obstructive pulmonary disease (COPD). The latter, a disease of midlife and later, though more common in men than in women, is a disease to which women smokers and never smokers may be more susceptible than men; it is… 
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Highly Influential Citations
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125 Citations

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Citation Type

17β-estradiol replacement reverses age-related lung disease in estrogen-deficient C57BL/6J mice.
TLDR
The data suggest that in the aging female mouse lung, estrogen deficiency and an increase of ERα expression lead to the development of an emphysematous phenotype, and estrogen replacement partially prevents these age-associated changes in the lung architecture by restoration of interalveolar septa.
Toward therapeutic pulmonary alveolar regeneration in humans.
TLDR
This work reviews animal models of alveolar loss and regeneration and their conservation during evolution, and hence their relevance to humans and their assessment of its feasibility.
Lung dysfunction causes systemic hypoxia in estrogen receptor β knockout (ERβ−/−) mice
TLDR
It is concluded that ERβ is necessary for the maintenance of the extracellular matrix composition in the lung and loss of ERβ leads to abnormal lung structure and systemic hypoxia.
Estrogen receptor regulation of pulmonary alveolar dimensions: alveolar sexual dimorphism in mice.
  • D. Massaro, G. Massaro
  • Biology, Medicine
    American journal of physiology. Lung cellular and molecular physiology
  • 2006
TLDR
The results in male mice demonstrate estrogen receptors have a smaller effect on alveolar dimensions in male than female mice, show ER-alpha and ER-beta are required for the sexual dimorphism ofAlveolar size, and showER-alpha is needed for the body mass-specific alveoli number and surface area.
The role of female hormones on lung function in chronic lung diseases
TLDR
Clinical and in-vivo data have demonstrated that females may be more susceptible to the pathogenesis of lung diseases, and the effect of female sex hormones in the context of these inflammatory airway diseases is reviewed.
Elderly Female Rhesus Macaques Preserve Lung Alveoli With Estrogen/Progesterone Therapy
TLDR
Hormone replacement could possibly slow the loss of alveoli due to the aging process or aid in alveolar regeneration through direct or indirect mechanisms.
Cell and Molecular Mediators involved in damage and repair in emphysema using mouse models
TLDR
This study shows that RAGE mediates early neutrophil recruitment leading to the pathogenic progression of alveolar damage and elucidates the contribution of a CC10 expressing bronchial progenitor arising from the distal airways leading toAlveolar repopulation in the context of emphysema.
Papain-induced experimental pulmonary emphysema in male and female mice
Regenerative pharmacology for COPD: breathing new life into old lungs
TLDR
It is argued that given the widespread and irreversible nature of COPD, serious consideration of regenerative pharmacology is necessary, and for this approach to be feasible, a better understanding of the cell-specific molecular control of regeneration, the regenerative potential of the human lung and regenerative competencies of patients with COPD are required.
17β-estradiol protects the lung against acute injury: possible mediation by vasoactive intestinal polypeptide.
TLDR
As it protected against injury, estradiol rapidly and significantly stimulated VIP mRNA expression in rat lung, and attenuated acute lung injury in three experimental models while stimulating VIP gene expression, a known mechanism of lung protection.
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References

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TLDR
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TLDR
It is concluded that estrogen is responsible for the sexual dimorphism of the lung's gas-exchange region and induces the formation of smaller, more numerous alveoli in otherwise untreated female rats.
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TLDR
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TLDR
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TLDR
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TLDR
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