Estrogen regulates placental androstenedione production during rat pregnancy.


During rat pregnancy the placenta appears to provide androgens, particularly androstenedione (delta 4A) as a source of precursor for estradiol (E2) formation by the ovary. The present study determined if the ovary and, specifically, estrogen have roles in regulating placental delta 4A production during the second half of rat pregnancy. Pregnant rats were… (More)