Estrogen regulates epithelial cell deformability by modulation of cortical actomyosin through phosphorylation of nonmuscle myosin heavy-chain II-B filaments.

@article{Li2006EstrogenRE,
  title={Estrogen regulates epithelial cell deformability by modulation of cortical actomyosin through phosphorylation of nonmuscle myosin heavy-chain II-B filaments.},
  author={Xin Li and Lingying Zhou and George I. Gorodeski},
  journal={Endocrinology},
  year={2006},
  volume={147 11},
  pages={
          5236-48
        }
}
The objective of the study was to understand how estrogen modulates the rigidity of the cytoskeleton in epithelial cells. Estrogen depletion decreased, and treatment with 17beta-estradiol increased deformability of cervical-vaginal epithelial cells. Estrogen also induced redistribution of nonmuscle myosin II-B (NMM-II-B); lesser interaction of NMM-II-B with actin; increased phosphorylation of NMM-II-B-heavy chains at threonine and serine residues; and decreased filamentation of NMM-II-B in… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-8 OF 8 CITATIONS

Purinergic Signalling in the Reproductive System

  • Autonomic Neuroscience
  • 2015
VIEW 7 EXCERPTS
CITES BACKGROUND, METHODS & RESULTS
HIGHLY INFLUENCED

References

Publications referenced by this paper.
SHOWING 1-10 OF 55 REFERENCES

ATP stimulates GRK-3 phosphorylation and beta-arrestin-2-dependent internalization of P2X7 receptor.

  • American journal of physiology. Cell physiology
  • 2005
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Estrogen abrogates transcervical tight junctional resistance by acceleration of occludin modulation.

  • The Journal of clinical endocrinology and metabolism
  • 2004
VIEW 6 EXCERPTS
HIGHLY INFLUENTIAL

Similar Papers