Estrogen regulated proteases and antiproteases in ovarian and breast cancer cells

@article{Rochefort2001EstrogenRP,
  title={Estrogen regulated proteases and antiproteases in ovarian and breast cancer cells},
  author={Henri Rochefort and Dany Chalbos and S{\'e}verine Cunat and Aur{\'e}lie Lucas and Marcel Garcia},
  journal={The Journal of Steroid Biochemistry and Molecular Biology},
  year={2001},
  volume={76},
  pages={119-124}
}
Cathepsin D (cath-D), an estrogen-regulated protease appears mostly to increase the number of tumor cells rather than their invasion or motility through the extracellular matrix. Estradiol is mitogenic but in vitro it also inhibits invasion and motility. In this review, we discuss the mechanism of this inhibition and the hormonal regulation of other proteases and protease inhibitors possibly involved in the control of tumor cell invasion by estrogens. 

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