Estrogen reduces lipid content in the liver exclusively from membrane receptor signaling.

@article{Pedram2013EstrogenRL,
  title={Estrogen reduces lipid content in the liver exclusively from membrane receptor signaling.},
  author={Ali Pedram and Mahnaz Razandi and Fiona O'Mahony and Harry Harvey and Brian J Harvey and Ellis Robert Levin},
  journal={Science signaling},
  year={2013},
  volume={6 276},
  pages={ra36}
}
Estrogen induces signal transduction through estrogen receptor α (ERα), which localizes to both the plasma membrane and nucleus. Using wild-type mice, ERα knockout (ERKO) mice, or transgenic mice expressing only the ligand-binding domain of ERα exclusively at the plasma membrane (MOER), we compared the transcriptional profiles of liver tissue extracts after mice were injected with the ERα agonist propyl-pyrazole-triol (PPT). The expression of many lipid synthesis-related genes was comparably… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 72 times. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 25 extracted citations

Estrogen, Angiogenesis, Immunity and Cell Metabolism: Solving the Puzzle

International journal of molecular sciences • 2018
View 1 Excerpt

Cohort of estrogen-induced microRNAs regulate adrenomedullin expression.

American journal of physiology. Regulatory, integrative and comparative physiology • 2016
View 1 Excerpt

Similar Papers

Loading similar papers…