Estrogen reduces CCL4- induced liver fibrosis in rats.

  title={Estrogen reduces CCL4- induced liver fibrosis in rats.},
  author={J Xu and Jun Gong and Xin-ming Chang and Jin-yan Luo and Lei Dong and Zhi-ming Hao and A B Renyong Jia and Gui-ping Xu},
  journal={World journal of gastroenterology},
  volume={8 5},
AIM Chronic liver diseases, such as fibrosis or cirrhosis, are more common in men than in women. This gender difference may be related to the effects of sex hormones on the liver. The aim of the present work was to investigate the effects of estrogen on CCL(4)-induced fibrosis of the liver in rats. METHODS Liver fibrosis was induced in male, female and ovariectomized rats by CCL(4) administration. All the groups were treated with estradiol(1 mg/kg) twice weekly. And tamoxifen was given to… CONTINUE READING