Estrogen recruits the endocannabinoid system to modulate emotionality

  title={Estrogen recruits the endocannabinoid system to modulate emotionality},
  author={M. Hill and Eda S. Karacabeyli and B. Gorzalka},
  • M. Hill, Eda S. Karacabeyli, B. Gorzalka
  • Published 2007
  • Psychology, Medicine
  • Psychoneuroendocrinology
  • Estrogen administration elicits anxiolytic and antidepressant-like effects in female rats; however, the mechanism of this effect is unknown. Fatty acid amide hydrolase (FAAH), the enzyme which degrades the endocannabinoid anandamide, has been shown to be regulated by estrogen. Thus, we examined if the anxiolytic and antidepressant effects of estrogen implicated the endocannabinoid system. In the first experiment, ovariectomized female rats were administered a single injection of 17beta… CONTINUE READING
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    Publications referenced by this paper.
    Behavioral despair in mice: a primary screening test for antidepressants.
    • 2,946
    Modulation of anxiety through blockade of anandamide hydrolysis
    • 829
    • Highly Influential
    • PDF
    Role of endogenous cannabinoids in synaptic signaling.
    • 1,401
    • PDF
    Antidepressant-like activity and modulation of brain monoaminergic transmission by blockade of anandamide hydrolysis.
    • 583
    • PDF
    Endocannabinoid system and stress and anxiety responses
    • 403
    Novel Actions of Estrogen Receptor-β on Anxiety-Related Behaviors
    • 334
    • PDF
    Effects of the cannabinoid CB1 receptor antagonist rimonabant in models of emotional reactivity in rodents
    • 228
    • PDF
    Anxiolytic-Like Properties of the Anandamide Transport Inhibitor AM404
    • 195
    • PDF
    Antidepressant-like and anorectic effects of the cannabinoid CB1 receptor inverse agonist AM251 in mice
    • 163