Estrogen receptors alpha and beta differentially regulate the transcriptional activity of the Urocortin gene.

@article{Haeger2006EstrogenRA,
  title={Estrogen receptors alpha and beta differentially regulate the transcriptional activity of the Urocortin gene.},
  author={Paola Haeger and Mar{\'i}a Estela Andr{\'e}s and Mar{\'i}a In{\'e}s Forray and Claudia Daza and Silvia Araneda and Katia Gysling},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2006},
  volume={26 18},
  pages={4908-16}
}
Urocortin (Ucn), a highly conserved metazoan gene, is related to stress and feeding, behaviors with significant gender differences. We investigated whether estrogens regulate the expression of the Ucn gene using transient transfection in PC12 cells with the human Ucn (hUcn) promoter coupled to luciferase and either alpha or beta estrogen receptors (ERalpha or ERbeta, respectively). The results demonstrate that estradiol (E2) increases the activity of the hUcn promoter via ERalpha, and decreases… CONTINUE READING

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