Estrogen receptors alfa (ERα) and beta (ERβ) differentially regulate proliferation and apoptosis of the normal murine mammary epithelial cell line HC11

Abstract

The mitogenic effect of 17β-estradiol (E2) on the breast is mediated by estrogen receptor alfa (ERα), hence ERα antagonists are effective in the treatment of breast cancer. The possible use of estrogen receptor beta (ERβ) as a target in treatment of breast cancer is under investigation. The mouse mammary cell line HC11 expresses both ERs and was used to… (More)
DOI: 10.1038/sj.onc.1208807

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@article{Helguero2005EstrogenRA, title={Estrogen receptors alfa (ERα) and beta (ERβ) differentially regulate proliferation and apoptosis of the normal murine mammary epithelial cell line HC11}, author={Lu{\'i}sa A Helguero and Malin Hedengran Faulds and Jan-{\AA}ke Gustafsson and Lars-Arne Haldos{\'e}n}, journal={Oncogene}, year={2005}, volume={24}, pages={6605-6616} }