Estrogen receptors' roles in the control of mechanically adaptive bone (re)modeling.

@article{Galea2013EstrogenRR,
  title={Estrogen receptors' roles in the control of mechanically adaptive bone (re)modeling.},
  author={Gabriel L Galea and Joanna S. Price and Lance E. Lanyon},
  journal={BoneKEy reports},
  year={2013},
  volume={2},
  pages={
          413
        }
}
The discovery that estrogen receptors (ERs) are involved in bone cells' responses to mechanical strain offered the prospect of establishing the link between declining levels of circulating estrogen and the progressive failure of the mechanically adaptive mechanisms that should maintain structurally appropriate levels of bone mass in age-related and post-menopausal osteoporosis. Such clarification remains elusive but studies have confirmed ligand-independent involvement of ERs as facilitators in… CONTINUE READING

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Bone Quality and Quantity are Mediated by Mechanical Stimuli

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